Milk Thistle

[swimfan30]

For the bro's that use or have used milk thistle along with a 17 oral: How many mgs. per day is sufficient. The directions on my brand say anywhere from 200 to 600 mgs. a day. Should I just follow that on my current cycle?

[The BB Monad]

Run the milk thistle post-cycle and during cycle run Synthergine or Liv52 if you are counting your dollars.

[JUICEDUP3]

i take 1000mg a day, every day.. which thats only one pill

[buff86]

Run the milk thistle post-cycle and during cycle run Synthergine or Liv52 if you are counting your dollars.

Bump.Sounds like a plan for me too.

[dudcki27]

Bump.Sounds like a plan for me too.

Sorry to change the subject but, buff86 do you really think that the pct you have planned is going to be enough for your current cycle? It looks pretty weak to me.

[buff86]

Sorry to change the subject but, buff86 do you really think that the pct you have planned is going to be enough for your current cycle? It looks pretty weak to me.

That was for my previous cycle and yes it was weak. This go around I'll increase the dosage of nolva and run clomid along side as well. I was a bit emotional when I came off that last cycle.lol Im confident my natty levels came back though. Still strong and always ready to fuck. It took about 3 wks to come back around though. Ive read in some studies that nolva was just as effective at raising Lh and test at 20 mg ed as was 100, minus any sides. Didnt wanna over do it with the nolva. I apologize board for jumping off topic here. thanks.

[Mikillium]

The directions say 1, 3 times a day. So I figured with the harsh shit we run I went with 2, 3 times a day and 2 gal of water! Now I'm done with orals so I went back to rec dose! I didn't have ne problems but I didn't get blood work done either to check values during orals.

[skizzyfan21]

I thought I remember reading a thread on here advising not taking milk thistle while on cycle or something? I would just stick with Liv 52! I might be wrong

[buff86]

I thought I remember reading a thread on here advising not taking milk thistle while on cycle or something? I would just stick with Liv 52! I might be wrong

Ive heard the same. I pulled this from another discussion : Milk Thistle: Good for Livers, Potentially Bad for Gains

Title: Silymarin inhibits function of the androgen receptor by reducing nuclearlocalization of the receptor in the human prostate cancer cell line LNCaP.Authors: Zhu W, Zhang JS, Young CY.Source: Carcinogenesis 2001 Sep;22(9):1399-403
Research Summary
Agents with novel mechanisms of blocking androgen receptor (AR) function may be useful for prostate cancer prevention and therapy. Previous studies showed that silibinin (SB), the major active component of Milk Thistle, could inhibit cell proliferation of a human prostate cancer cell line by stopping the cell cycle without causing cell death. This study further demonstrates the potential molecular mechanism by which Milk Thistle acts on androgen-responsive prostate cancer cells by inhibiting function of the AR. We observed that Silymarin (SM) and SB inhibited androgen-stimulated cell proliferation as well as androgen-stimulated secretion of both prostate-specific antigen (PSA) and human glandular kallikrein (hK2).Additionally, for the first time, we show that SM and SB diminished transactivation activity of the AR. However, SM did not affect AR levels and steroid-binding ability of total AR in western blotting and ligand-binding assays. Intriguingly, we found that nuclear AR levels are significantly reduced by SM and SB in the presence of androgens. This study provides a new insight into how Milk Thistle negatively modulates androgen action in prostate cancer cells.

Discussion

Milk Thistle is a popular bodybuilding supplement and is currently the most well researched plant for the treatment of liver disease (with over 450 published peer review papers). Silymarin, a flavonoid extract from Milk Thistle, has been used clinically for alcoholic liver disease treatment in Europe and Asia for almost 2,000 years. Currently it?s used by bodybuilders as a protective measure for the liver when using high doses of orals.Silymarin is not water soluble and is typically administered as an encapsulated standardized extract. The absorption with oral administration is rather low, with only two to three percent being effectively taken up. The peak plasma levels after an oral dose are achieved in four to six hours. The reason this study is significant is because of the described mechanism that Milk Thistle is working in the prostate. It is showing effectiveness in treating prostate cancer because it prevents the androgen receptor from making it to the nucleus of the cell. This may be good if you are fighting cancer of the prostate, but it is bad if you are trying to get a muscle cell to grow larger.In order for testosterone to work, it must pass from the blood to the inside of a muscle cell, bind to the androgen receptor inside the cell, then travel inside the nucleus where it binds to your DNA.These researchers were able to show that Milk Thistle did not reduce the number of androgen receptors, nor did it prevent androgens (i.e., testosterone) from binding to the receptors. All it seemed to do was prevent the androgen receptor from traveling to the nucleus, and in our case, this prevents the desired effect. The androgen receptor, once bound to the androgen, must make it to the nucleus in order to increase protein synthesis.Bottom line: Use Milk Thistle if you are sure you are having liver toxicity problems. Then, only use it for a few weeks at a time.
Seems like a valid reason to use it pct as opposed to on cyle. Im gonna run the liv52 and alpha lipoic acid while on, milk thistle pct.

[Reginald]

Run the milk thistle post-cycle and during cycle run Synthergine or Liv52 if you are counting your dollars.

if I buy Synthergine, it's sufficient it own alone(i.e. can I use it post-cycle in the place of milk thistle??),or has better if I buy milk thistle too??

...and ..what store does milk thistle sell?? I've not able to find it.

However the main question is : if I own Synthergine...I can use it in post-cycle or milk thistle has/is more suitable??

[buff86]

I think its a matter of whats on hand. If you have synthergine Id run with that as Ive heard nothing but good about it. Throughout cycle and post cycle as pct orals may tax the liver aswell. As far as where you can find milk thistle, walmart carries it and the dollar store carrys it too. It should be with all the vitamains and supps in most any strore.However, if you felt it nessecary to run milk thistle pct in addition to synthergine I dont think it would hurt.imo

[Reginald]

I think its a matter of whats on hand. If you have synthergine Id run with that as Ive heard nothing but good about it. Throughout cycle and post cycle as pct orals may tax the liver aswell. As far as where you can find milk thistle, walmart carries it and the dollar store carrys it too. It should be with all the vitamains and supps in most any strore.However, if you felt it nessecary to run milk thistle pct in addition to synthergine I dont think it would hurt.imo

ok thank u bro

[swimfan30]

Out of Liv 52. That why I switched. I'm not looking for mass gains. Thanx for the literature fellas!

[dr intensity]

Out of Liv 52. That why I switched. I looking for mass gains. Thanx for the literature fellas!

man liv 52 is one awesome liver detoxifier i administer 6 single strength tabs/ daily on cycle or off cycle... my LFT values have always been awesome:) always

[swimfan30]

Good to know Mr. Intensity. I will get that postcard from Alin in the future because it is much less dough!!

[Reginald]

May I get Liv52 in pharmacy without a medical prescription,right?
Compare it to Synthergine ,what's the main differences? which is more powerfull?

[Big A]

May I get Liv52 in pharmacy without a medical prescription,right?
Compare it to Synthergine ,what's the main differences? which is more powerfull?

Nothing is stronger that Synthergine. Google each individual ingredient and you'll see.

[Alin]

For the bro's that use or have used milk thistle along with a 17 oral: How many mgs. per day is sufficient. The directions on my brand say anywhere from 200 to 600 mgs. a day. Should I just follow that on my current cycle?

I'd run Synthergine myself. Its the best liver protectant you can buy.

[Reginald]

yes,it wake up the deads!
it's a pity they dont start to create any very powerful stuff for prostate safeguard too,hair as well