cjc 1295

[lostwars]

anyone used this new peptide, seen a guy who has tried nearly every peptide out there and he rates the cjc better than growth hormone
he also said igf and mgf and the like are a waste of money, i know a source who those a nice price on 2mg vial of cjc so ill try some out after xmas with my spring bulker
this aint a slaes pitch so no pms asking for my source

[HybridTheory]

From what i remember reading about it, its a much more stable derivative of GHRH (growth hormone releasing hormone). The problem with GHRH was that it had a half-life of literally only a few minutes, due to a strong attraction of aminos that rendered it inactive.

So with CJC1295 they were able to synthesize and use a newer method called bioconjugation to increase the half life to almost a full week. With such an increase in bioavailability/activity you can use it once a week for great results (2x being optimal). I dont remember the numbers on it but they were very substantial for IGF-1 and GH concentration levels.

Another great factor for this peptide is price relative to HGH, with the former being significantly lesser.

*I will try to find the write-up i read about this and paste it here.

Edit - Write up i read over at AM by LMD:

GHRH1-44, also known as Growth Hormone Releasing Hormone (other synonyms are GRF and GHRF), is a peptide that is produced in the hypothalamus and secreted to stimulate the release of human growth hormone (hGH). It consists of a 44 amino acid long sequence and is released in a pulsatile fashion similar to the pulsatile release of hGH. The active portion of this peptide can be found as a 29 amino acid long peptide and is appropriately named GHRH1-29. This pulsatile release of various peptides is due to the negative feedback loop that is part of the hGH axis and controls the amount of hGH that your body produces to keep it in a homeostatic environment. Despite the effectiveness of GHRH to stimulate growth hormone release there are a number of problems associated with using it in vivo. The most noteworthy problem is the half life of the peptide, which has been shown to be ~7 minutes using advanced HPLC technologies that have proven to be very accurate. The reason for this relatively short half life is due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV), which has a high affinity for the amino acids Ala and Pro and in the case of GHRH it cleaves the 1 and 2 positions that consist of Tyr-Ala, creating GHRH3-29, an inactive form of the peptide. To prevent the problems associated with natural GHRH, pharmaceutical companies looked at new ways to increase the half life and bioavailability of these smaller peptides with technologies that work far different than other technologies, such as PEGylation.

This brings us to the introduction of a far more stable form of GHRH called CJC-1295. CJC-1295 is a tetrasubstituted peptide analogue of GHRH with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days! Bioconjugation is a relatively newer technology that takes a reactive group and attaches it to a peptide, which in turn reacts with a nucleophilic (usually a partially negative molecule) entity found in the blood to form a more stable bond. Albumin, one of the most abundant substances in the human body is chosen as the nucelophile by this particular peptide thanks to a Cys34 thiol group that attracts it. By combining the tetrasubstituted GHRH analogue with maleimodoproprionic acid using a Lys linker, you create a GHRH peptide with a high binding affinity for albumin. Once the CJC-1295 molecule has attached itself to albumin, it is given an extended half life and bioavailability thanks to the albumin preventing enzymatic degredation and kidney excretion. In fact, bioconjugation is so effective that there was less than 1% of CJC-1295 left unreacted in vivo and over 90% was stabilized after subcutaneous injection. This means that you get more of what you paid for working for you. There was no DPP-IV degredation observed on CJC-1295 in any of the various experiments conducted.

Due to the extremely long half life of CJC-1295 it is plausible to use this peptide once per week with outstanding results. Much like compounds such as testosterone enanthate, however, it would be wiser to use ½ dosages twice per week to keep serum levels high and to get maximal GH release and limit the pulsatile fashion of hGH. Various experiments have been conducted to test the effectiveness of CJC-1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection! Not only that but they proved the mean half life to be 5.8-8.1 days and after multiple doses showed mean IGF-1 levels remained above baseline for up to 28 days following! No serious adverse reactions were reported in any group. The graphs below show that this peptide has the ability to stimulate growth hormone very significantly and is much more cost effective than illegally buying hGH.

Another very positive benefit of CJC-1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. SWS is decreased significantly in older adults and also with people who tend to exercise later in the evening. This peptide has a benefit to side effect ratio that exceeds all others currently being legally sold and would make a great addition to ones training regimen or post cycle therapy.

[skullcrusher01504]

There is only one problem with that... the following is from DATBTRUE

"In short Chinese facilities were not equipped to manufacture CJC-1295. It is a complex and costly process. The drug affinity complex must be made outside of a peptide synthesizer and then added into the peptide creation process. CJC-1295 unlike modified GHR(1-29) or the GHRPs (Hexarelin, GHRP-6, GHRP-2, etc.) is not a pure peptide.

For whatever reason these facilities decided to label modified GRF(1-29) as CJC-1295.

It is important to remember that a CoA certificate comes from the same facility that produced the peptide in the first place (even sellers of bulk herbs use the CoA from the original seller). Very rarely does anyone in the supplement business get an independent analysis done on their compound.

So with that being said those who ran modified GRF(1-29) labeled CJC-1295 in accordance with what has become known as Dat's protocol (What a stupid name Dat. Who would ever listen to a Dat anyway?) saw very good benefit. They administered modified GRF(1-29) along with GHRP-6 three times a day. They amplified the largest pulse of the day in males (the night pulse). They had a pulse of GH when they were at their most catabolic (in the morning) which probably carried over into reducing protein degradation while they worked out later and they had a pulse after their workout which increased protein synthesis, worked well with elevated insulin levels (probably from PWO carbs) and skewed nutrient partitioning in favor of muscle anabolism.

Those individuals created 21 GH pulses for the week.

Those that did not use Dat's protocol administered modified GRF(1-29) labeled as CJC-1295 twice a week which gave them 2 GH pulses for the week. Also it is likely that the body could only use a small portion of the 1mg of modified GRF(1-29) administered in a single dose."

SO you would be better off using GRF(1-29) instead of CJC-1295.

[Alin]

anyone used this new peptide, seen a guy who has tried nearly every peptide out there and he rates the cjc better than growth hormone
he also said igf and mgf and the like are a waste of money, i know a source who those a nice price on 2mg vial of cjc so ill try some out after xmas with my spring bulker
this aint a slaes pitch so no pms asking for my source

I have not used it. Try it and let us know. Post your results.

[Jello]

I have read in a couple places that it can cause a "GH Bleed"

What the hell is that and could someone give some kind of credible explanation of what that means?

[skullcrusher01504]

I have read in a couple places that it can cause a "GH Bleed"

What the hell is that and could someone give some kind of credible explanation of what that means?

Anyway

"Cell-to-cell communication is also likely to reflect the density and proximity of adjacent cells as GH responsiveness (but not sensitivity) to GHRH is enhanced at higher densities and basal GH release is greatest at low densities."

"Cell-to-cell contact may therefore affect the cellular integrity of somatotrophs because GH synthesis or secretory granule storage may be better maintained in high density cell concentration then in low-density concentrations." - Growth Hormone, Stephen Harvey

What happens is cells in the pituitary communicate. They self organize and create a firing network for coordinated growth hormone release. This communication creates a high density of GH releasing cells. They are in close proximity through their communicatory network. The cells have specific spatial relationships that may be modulated by peripheral endocrines. These include sex steroids, thyroid hormones, glucorticoids and even the pancreatic and gut hormones. Their spatial relationship is also effected by physiological state such as nutrient status, age and pregnancy.

As a quick example, corticotroph, thyrotrophs and folliculostellate cells are in close proximity to somatotrophs and communicate with them through gap junctions (almost like just reaching out and touching signaling). They have the potential to effect and be effected by their neighbors.

What happens when you have GHRH always around is you force these somatotrophs to release GH because they are sensitive to the GHRH binding to them and effecting release. By constantly occupying you are preventing them from coordinating with surrounding cell populations. You force these cells to act as low density subpopulations. Basal GH release is greatest when you can disperse the spatial relationship between somatotrophs and that is what an always on GHRH will do.

CJC-1295 as an always on GHRH will force upon somatotrophs loner behavior with a single constant chore. This reduces GH responsiveness as this only occurs when somatotrophs can communicate, self organize and maintain social relationships with the surrounding community. These types of social somatotrophs are better able to make and store GH then the loner cells.

So CJC-1295 seems to disperse somatotrophs and enslave them getting less from them then if it had just let them congregate in towns and cities.

Aging has an effect on the vitality of city centers as well and as we age these somatotroph population centers become less vigorous. By using a more physiological GHRH such as modified GRF(1-29) together with a modulator GHRP-2 we revitalize that inner city and allow our cells to be more social and thus more productive. If instead we choose to use CJC-1295 we not only fail to remedy the problem associated with age , but we may end up exacerbating it.

I conjecture that it also makes them better neighbors to corticotroph, thyrotrophs and folliculostellate cells as well.

Quoted from DATBTRUE

[HybridTheory]

C
SO you would be better off using GRF(1-29) instead of CJC-1295.

I never researched it beyond what I quoted and read a few years ago. So i was a little behind haha. Apparently from doing a few more cursory searches that the long-ester compound can be found on an expensive budget (contrary to the original projection). Those that have actually tried the true peptide (DAC inclusion) apparently have had much success. The best bet for any one person is to not go off anecdotes and use the beyond reproach method; which would be to examine the molecular weight to see if the DAC (via the lysine linker) was substituted.

The DAC (drug affinity complex) is the necessary component to the CJC debacle, aka the modified version of GRF(1-29). So actually you're better off not using either unless it is synthesized to include it. Also as the the text you quoted shows if one where to use the DAC-less CJC-1295 (or modified GRF (1-29)) then it would be most beneficial used in conjunction with GHRP. due to the great synergistic properties. So lostwars definitely do your research to know exactly what you are dealing with.

[lostwars]

jesus thats a bummer, suppose we gotta expect it when dealing with research compounds and never really having a guarantee of its quality or if its legit cjc1295
i may just dip me toe into the muddy waters and try a little of it on my next cycle
thanks again for all the info men, some great research there

[HybridTheory]

also an addendum to clarify things. in the post i was responding to, the info given was about the same compound (DAC-less CJC-1295 = modified GRF (1-29)) not two different ones. so im assuming skullcrusher misspoke when saying it would be better to take GRF (1-29); obviously it wouldnt because its the same as the intial compund being discussed.

Im not sure if he happened to be talking about the the unmodified version of GRF (1-29) though. If that were the case then the former would still be the better option (+GHRP-6) of the two.

[skullcrusher01504]

My point was almost no one makes CJC-1295 anymore it cots to much. the just label mod(1-29) as CJC-1295 and mark it up. so save your money and use the mod(1-29). if I am mistaken Sorry but that is what I get from my readings.