How much Vitamin B12 is standard?

[Cadillacman]

I purchased some B12 to inject but am unsure what a common dosage is?

I use to get one from my old Dr every now and then but can't remember how much to use.

Anyone out there using B12 daily, weekly or monthly?

Any info would be great.

[allnatty06]

I usually go 1cc EOD or 1cc every 3rd day. I think if your getting it for medical reason ( given to eldery a lot) 1cc per week. But for bbing i feel that a bit more is needed. It's great for your immune system and your appetite, and gives you alot of energy as well, GOOD LUCK!!!!

[Cadillacman]

I thought it would help me with energy since I started training again. I have been dreading my 6 am wakup but I gotta do it.

So if I did a half (.5) cc a day do you think that would be too much or should I stick with a higher dosage less often?

[allnatty06]

well, less injections is always a plus.. you can easily do eod, or every third day, it's no like it's any sort of short ester or anything. At 6 A.M.????? that's way to early for me, unless it's cardio on an empty stomach, i can't lift in the morning....... too tired, only cardio for me.

[liquidC]

When I'm bulking up, I eat a lot of red meat. During that time I take a couple of CC's a week or so. When I'm cutting for a contest, I eat only fish and bonless skinless chicken breast. During that time since I am taking so many other injections, I take 1 CC a day at night time Sub Q with an insulin pin to help substitue for some of the important vitamins lost not eating the red meat. EOD or even 2x a week should be fine. You can't really OD on it as your body will just piss out the excess it doesn't need.

[sammarbella]

I purchased some B12 to inject but am unsure what a common dosage is?

I use to get one from my old Dr every now and then but can't remember how much to use.

Anyone out there using B12 daily, weekly or monthly?

Any info would be great.

B12 has a half-life of 3 hours (like any other water soluble vitamin).

I prefer (and use) a special form of B12: cobamamide(aka dibencozide).

Cobamamide is co-enzyme B-12 who has a half life of 12 hours(serum) so i use one in breakfast and one on dinner.

Mine has a 3000mcgs (3 mgs) per cap and i buy it in my local pharmacy without prescription.

[Big A]

Oral B12 in any form is a waste of time and money as the stomach destroys it.

Injectible is the only way to effectively administer it.

99% of inj. B12 available is cyanacobalamin which means you have to inject it daily, no matter what. And you have to use 1,000mcg/day.

If you bought Synthelamin from our sponsors here www.synthetek.com, then it's a timed release inj B-12 that contains cyancobalamin and hydroxycobalamin so you only hvae to inject it once or twice a week. It is the only one on the market like that and it's also 2,000mcg per ml.

You can't overdose with B12, you will just piss it out.

[Kaiser]

Oral B12 in any form is a waste of time and money as the stomach destroys it.

Injectible is the only way to effectively administer it.

99% of inj. B12 available is cyanacobalamin which means you have to inject it daily, no matter what. And you have to use 1,000mcg/day.

If you bought Synthelamin from our sponsors here www.synthetek.com, then it's a timed release inj B-12 that contains cyancobalamin and hydroxycobalamin so you only hvae to inject it once or twice a week. It is the only one on the market like that and it's also 2,000mcg per ml.

You can't overdose with B12, you will just piss it out.


Believe it or not A, I have never used injectable B-12. What can be expected from it besides the obvious energy boost?

[Alin]

B12 has a half-life of 3 hours (like any other water soluble vitamin).

I prefer (and use) a special form of B12: cobamamide(aka dibencozide).

Cobamamide is co-enzyme B-12 who has a half life of 12 hours(serum) so i use one in breakfast and one on dinner.

Mine has a 3000mcgs (3 mgs) per cap and i buy it in my local pharmacy without prescription.


You should use the Synthetek brand. FAR superior than ANY B12 ever available. It's great for energy and to increase appetite.

[allnatty06]

Believe it or not A, I have never used injectable B-12. What can be expected from it besides the obvious energy boost?
well, as i said above, it increases energy, appetite, and builds up your immune system...

[kaelalden]

Is it safe for females? because she is always tired.
And do you have to keep it refrigerated after opened?

[Cadillacman]

Oral B12 in any form is a waste of time and money as the stomach destroys it.

Injectible is the only way to effectively administer it.

99% of inj. B12 available is cyanacobalamin which means you have to inject it daily, no matter what. And you have to use 1,000mcg/day.

If you bought Synthelamin from our sponsors here www.synthetek.com, then it's a timed release inj B-12 that contains cyancobalamin and hydroxycobalamin so you only hvae to inject it once or twice a week. It is the only one on the market like that and it's also 2,000mcg per ml.

You can't overdose with B12, you will just piss it out.

Sorry I could have gotten it from the sponsor but I purchased it here
http://www.researchlabsupply.com/Scripts/prodView.asp?idproduct=35

It's the B12 you described above but I just caught the fact it's recomended for cattle, sheep and swine! LOL I've been called a pig before but do you think this is okay for human consumption? LOL

Always read the label....hahahaha!

A little help guys...

[Kaiser]

well, as i said above, it increases energy, appetite, and builds up your immune system...


I know what you said above. I am sorry I was looking for a vet to answer the question. Anyone could read that on the net or in a book, been there read that. I was looking for a BBers perspective especially on Synth's B-12 because I would use no other due to it's preservatives.

[sammarbella]

Oral B12 in any form is a waste of time and money as the stomach destroys it.

Injectible is the only way to effectively administer it.

99% of inj. B12 available is cyanacobalamin which means you have to inject it daily, no matter what. And you have to use 1,000mcg/day.

I don't want to flame you but...

I must agree that injected B12 is the better way to take BUT oral forms of b12 or cobamamide(dibencozide) are not a waste of time or money.

Take a look at this study (1 minute search in google, there is plenty of):

The Coenzyme Forms of Vitamin B12: To-
ward an Understanding of theirTherapeutic
Potential

Gregory Kelly, N.D.

http://www.thorne.com/altmedrev/fulltext/b122-6.html

or

http://www.thorne.com/pdf/journal/2-6/coenzymeb12.pdf

(extracts):

.................................................. ............................
Introduction
Cyanocobalamin (CN-Cbl) is the most commonly supplemented form of vitamin B12,
but it is present in the body in trace amounts and its biochemical significance remains uncertain.
Although the amount of cyanide is considered toxicologically insignificant, humans must re-
move and detoxify the cyanide molecule, reduce the cobalamin to its usable +1 oxidation state,
and then enzymatically convert the cobalamin into one of two metabolically active coenzyme
forms. Nutritional inadequacies, enzyme defects, and pathological changes to tissues can all
contribute to a reduced ability of the body to accomplish the synthesis of the active forms of
vitamin B12 from CN-Cbl.
The two forms of vitamin B12 having activity in B12-dependent enzymes within the
human body are adenosylcobalamin (AdeCbl) and methylcobalamin (MetCbl). AdeCbl is occa-
sionally referred to as coenzyme B12, cobamamide, cobinamide, or dibencozide. In some bio-
chemical or therapeutic situations, the clinical utilization of either AdeCbl or MetCbl (alone or
in combination) can produce results not found with the supplementation of either CN-Cbl or
hydroxycobalamin (OH-Cbl)


.................................................. ..........
Absorption
Evidence indicates cobalamin from
MetCbl is utilized more efficiently than CN-
Cbl to increase the levels of coenzyme forms
of vitamin B12. Although free MetCbl is not
very stable in the gastrointestinal tract, and
considerable loss of the methyl group can take
place under experimental conditions, in physi-
ological situations intrinsic factor probably
partially protects MetCbl from degradation.
Paper chromatography of digested ileal mu-
cosa has demonstrated unchanged absorption
of MetCbl following oral administration. The
quantity of cobalamin detected following a
small oral dose of MetCbl is similar to the
amount following administration of CN-Cbl;
but, significantly more cobalamin accumulates
in liver tissue following administration of
MetCbl. Human urinary excretion of MetCbl
is about one-third that of a similar dose of CN-
Cbl, indicating substantially greater tissue re-
tention.
7
In humans, about 35 percent of AdeCbl
appears to be absorbed intact following oral
administration, and about 77 percent of the ab-
sorbed oral dose is retained in body tissues.
Although a higher percentage of CN-Cbl ap-
pears to be absorbed, only 50 percent is re-
tained in tissues, and assuming an adequate
supply of necessary cofactors is available,
probably is converted to the coenzyme forms
of vitamin B12 over a period of 1-2 months.
8
Although individuals with pernicious
anemia do not produce the intrinsic factor
needed for vitamin B12 absorption, high doses
of oral vitamin B12 (above 1000 mcg) have
been shown to be an adequate treatment of B12
deficiency and pernicious anemia, indicating
there is some mechanism of absorption inde-
pendent of intrinsic factor.
9, 10
It is likely that
with supra-physiological doses of the coen-
zyme forms of vitamin B12, some of the ab-
sorption is also independent of intrinsic fac-
tor.
.................................................. ...........................





Normally i use 3000 mcgs oral form of Cobamamide 2 times per day and with that i think i have plenty AVALAIBLE form of B12.

[sammarbella]

Also from previous study:

Dosage and Toxicity

A therapeutic dose for conditions requiring MetCbl would be a minimum of 1500 mcg and a maximum of 6000 mcg per day. No significant therapeutic advantage appears to occur from dosages exceeding this maximum dose; however, it is likely that beneficial physiological effects occur at dosages as low as 100 mcg per day, especially if this dose is given repetitively over time.

A therapeutic dose for AdeCbl is 1000-6000 mcg per day. Similarly, some physiological benefits are likely to occur at repetitive doses far below this therapeutic range.

Both MetCbl and AdeCbl have been administered orally, intramuscularly, and intravenously; however, positive clinical results have been reported irrespective of the method of administration. It is not clear whether any therapeutic advantage is gained from non-oral methods of administration.

MetCbl and AdeCbl have usually been administered in divided doses three times daily. These supplements have excellent tolerability and no known toxicity. AdeCbl has been administered safely during pregnancy. No rationale exists to suspect MetCbl would not also be safe during pregnancy.

Conclusion

AdeCbl and MetCbl are the coenzyme forms of vitamin B12 utilized in the vitamin B12-dependent enzymes in humans. Because the coenzyme forms bypass several of the enzymatic reactions required for the formation of the functional forms of vitamin B12, they offer a theoretical advantage in cobalamin supplementation. Both AdeCbl and MetCbl are retained in the body better and increase tissue concentrations of cobalamin better than CN-Cbl. Additionally, the coenzyme forms of vitamin B12 demonstrate a range of activity and clinical results not shown by the other supplemental forms of vitamin B12.

It is important to remember that circulating levels of vitamin B12 are not always a reflection of tissue levels, and that even if an adequate supply of cobalamin appears in the circulation, a functional deficiency of the coenzyme forms might coexist in tissues and other body fluids. Although CN-Cbl will usually increase circulating levels of cobalamin, its ability to increase tissue levels of the active forms of vitamin B12 can be limited in a range of sub-clinical and clinical conditions. Even in a best case scenario, the activation of CN-Cbl to either AdeCbl or MetCbl does not occur instantly, possibly occurring over 1-2 months, and requires the interaction of GSH, reducing agents, possibly alpha-tocopherol, and in the case of MetCbl, SAM and the active form of folic acid.

The use of either AdeCbl and/or MetCbl offers a significant biochemical and therapeutic advantage over other existing forms of vitamin B12, and should be considered as a first-line choice for correcting vitamin B12 deficiency and treating conditions shown to benefit from cobalamin administration.

[kaelalden]

What's the syringe gauge?

[Big A]

Interesting info on the diabencozide.

[Big A]

What's the syringe gauge?

You inject it IM or SQ. It's water based, so itgoes through anything, even 30g.

[Big A]

I know what you said above. I am sorry I was looking for a vet to answer the question. Anyone could read that on the net or in a book, been there read that. I was looking for a BBers perspective especially on Synth's B-12 because I would use no other due to it's preservatives.

B12 increases red blood cell count. So, you have more oxygen and nutrients transported around, as such more energy, metabolism increases, vascualarity increases, immune system increases and all these combined make you hungry.

[Big A]

Is it safe for females? because she is always tired.
And do you have to keep it refrigerated after opened?

It's non hormonal, so it is safe for women. As a matter of fact, women respond best to it as most are anaemic (easy to tell - they bruise easily).

It doesn't have to be refrigerated.

[terryd5150]

Oral B12 didn't do sh_t for me. :mad:

Just my .02. :D

[sammarbella]

Oral B12 didn't do sh_t for me. :mad:

Just my .02. :D

And what are you expecting from it?Anadrol effect? :D

Oral B12 has an half life of 3 hours so to have a steady level of vitamin in your body taking it orally you need to take it each 3 hours in high doses! (not very usefull)

If you want to take something effective use DAILY injection of B12 at 1000 mcgs dose or 2x3000mcgs co-enzyme B12 Cobabamide (dibencozide) each 12 hours (his hal life is 12 hours).