Adequan

[kingchaney]

Before I get bashed, I've searched all over this forum and the net, ... where can I find non-prescription Adequan?

[giff]

why do you want adequan?

[yafu]

Short version:

Adequan® Canine (polysulfated glycosaminoglycan) is a prescription, water-based, intramuscular, polysulfated glycosaminoglycan (PSGAG) that helps prevent the cartilage in your dog’s joint from wearing away. It helps keep the cartilage healthy and intact, so that the bone in the joint cannot touch other bones. No other drug for arthritis can do that.

Long version:

ADEQUAN ® CANINE Brand of Polysulfated Glycosaminoglycan Solution 100 mg/mL in a 5 mL preserved multiple dose vial for intramuscular use in dogs.
Caution: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description: The active ingredient in Adequan ® Canine is polysulfated glycosaminoglycan (PSGAG). Polysulfated glycosaminoglycan is a semisynthetic
glycosaminoglycan prepared by extracting glycosaminoglycans (GAGs) from bovine tracheal cartilage. GAGs are polysaccharides composed of repeating disaccharide units. The GAG present in PSGAG is principally chondroitin sulfate containing 3 to 4 sulfate esters per disaccharide unit. The molecular weight for PSGAG used in the manufacture of Adequan ® is 3,000 to 15,000 daltons.

Each mL of Adequan ® Canine contains 100 mg of PSGAG, 0.9% v/v benzyl alcohol as a preservative, and water for injection q.s. to 1 mL. Sodium hydroxide and/or hydrochloric acid added when necessary to adjust pH.

Pharmacology: The specific mechanism of action of Adequan ® in canine joints is not known. PSGAG is characterized as a “disease modifying osteoarthritis drug”. Experiments conducted in vitro have shown PSGAG to inhibit certain catabolic enzymes which have increased activity in inflamed joints, and to enhance the activity of some anabolic enzymes. For example, PSGAG has been shown to significantly inhibit serine proteinases. Serine proteinases have been demonstrated to play a role in the Interleukinl
mediated degradation of cartilage proteoglycans and collagen. PSGAG is reported to be an inhibitor of Prostaglandin E2 (PGE2) synthesis. PGE2 has been shown to increase the loss of proteoglycan from cartilage. PSGAG has been reported to inhibit some catabolic enzymes such as elastase, stromelysin, metalloproteases, cathepsin B1, and hyaluronidases, which degrade collagen, proteoglycans, and hyaluronic acid in degenerative joint disease. Anabolic effects studied include ability to stimulate the synthesis of protein, collagen, proteoglycans, and hyaluronic acid in various cells and tissues in vitro. Cultured human and rabbit chondrocytes have shown increased synthesis of proteoglycan and hyaluronic acid in the presence of PSGAG.
PSGAGs have shown a specific potentiating effect on hyaluronic acid synthesis by synovial membrane cells in vitro. Absorption,distribution, metabolism, and excretion of PSGAG following intramuscular injection have been studied in several species, including rats, rabbits, humans, horses and dogs.
Studies in rabbits showed maximum blood concentrations of PSGAG following IM injection were reached between 20 to 40 minutes following injection, and that the drug was distributed to all tissues studied, including articular cartilage, synovial fluid, adrenals, thyroid, peritoneal fluid, lungs, eyes, spinal cord, kidneys, brain, liver, spleen, bone marrow, skin, and heart.
Following intramuscular injection of PSGAG in humans, the drug was found to be bound to serum proteins. PSGAG binds to both albumin and chiand betaglobulins and the extent of the binding is suggested to be 30 to 40%. Therefore, the drug may be present in both bound and free form in the bloodstream. Because of its relatively low molecular weight, the synovial membrane is not a significant barrier to distribution of PSGAG from the bloodstream to the synovial fluid. Distribution from the synovial fluid to the cartilage takes place by diffusion. In the articular cartilage the drug is deposited into the cartilage matrix. Serum and synovial fluid distribution curves of PSGAG have been studied in dogs and appear similar to those found in humans and rabbits. In rabbits, metabolism of PSGAG is reported to take place in the liver, spleen, and bone marrow. Metabolism may also occur in the kidneys. PSGAG administered intramuscularly and not protein bound or bound to other tissues is excreted primarily via the kidneys, with a small proportion excreted in the feces.

Toxicity: In a subacute toxicity study, 32 adult beagle dogs (4 males and 4 females per treatment group) received either 0.9% saline solution or PSGAG at a dose of 5 mg, 15 mg, or 50 mg per kg of body weight (approximately 2.3, 6.8, or 22.7 mg/lb), via intramuscular injection twice weekly for 13 weeks. PSGAG doses represent approximately 1X, 3X, and 10X the recommended dosage of 2 mg/lb, and more than 3 times the recommended 4week duration of treatment.
Necropsies were performed 24 hours after the final treatment. During week 12, one dog in the 50 mg/kg dosage group developed a large hematoma at the injection site which necessitated euthanasia. No other mortalities occurred during the treatment period. Statistically significant changes in the 50 mg/kg group included increased prothrombin time, reduced platelet count, an increase in ALT and cholesterol, and increased liver and kidney weights. Increased cholesterol and kidney weights were also noted in the 15 mg/kg group.
Microscopic lesions were noted in the liver (Kupffer cells containing eosinophilic foamy cytoplasm), kidneys (swollen, foamy cells in the proximal convoluted tubules), and lymph nodes (macrophages with eosinophilic foamy cytoplasm) in the 15 mg/kg and 50 mg/kg groups. Intramuscular inflammation, hemorrhage, and degeneration were seen in all 3 PSGAG treated groups; the incidence and severity appeared dose related.

Efficacy: Efficacy of Adequan ® Canine was demonstrated in two studies. A laboratory study using radiolabeled PSGAG established distribution of PSGAG into canine serum and synovial fluid following a single intramuscular injection of 2 mg/lb. A clinical field trial was conducted in dogs diagnosed with radiographicallyconfirmed
traumatic and/or degenerative joint disease of 1 or 2 joints. Joints evaluated included hips, stifles, shoulders, hocks and elbows.
Fiftyone dogs were randomly assigned to receive either Adequan ® Canine at 2 mg/lb of body weight or 0.9% saline. Both treatments were administered by intramuscular injection twice weekly for 4 weeks (8 injections total). Investigators administering treatment and evaluating the dogs were unaware of the treatment assignment. A total of 71 limbs in 51 dogs were evaluated. Of these, 35 limbs in 24 dogs were in the Adequan ® Canine treated group.
Each lame limb was scored for lameness at a walk, lameness at a trot, pain, range of motion, and functional disability. The scores for the individual parameters were combined to determine a total orthopedic score. At the end of the treatment period, dogs treated with Adequan® Canine showed a statistically significant improvement in range of motion and total orthopedic score over placebo treated control dogs.

Indications and Usage: Adequan ® Canine is recommended for intramuscular injection for the control of signs associated with noninfectious degenerative and/or traumatic arthritis of canine synovial joints.

Contraindications: Do not use in dogs showing hypersensitivity to PSGAG. PSGAG is a synthetic heparinoid; do not use in dogs with known or suspected bleeding disorders.
Reproductive Safety: Studies to establish the safety of Adequan ® Canine in breeding, pregnant, or lactating dogs have not been conducted.

Precaution: Use with caution in dogs with renal or hepatic impairment.
Adverse Reactions: In the clinical efficacy trial, 24 dogs were treated with Adequan ® Canine twice weekly for 4 weeks. Possible adverse reactions were reported after 2.1% of the injections. These included transient pain at the injection site (1 incident), transient diarrhea (1 incident each in 2 dogs), and abnormal bleeding (1 incident). These effects were mild and selflimiting and did not require interruption of therapy. To report suspected adverse reactions or for a copy of the Material Safety Data Sheet for this product, contact Novartis Animal Health US, Inc. at 18006370281.

Human Warning: Keep this and all medications out of reach of children.
Dosage and Administration: The recommended dose of Adequan ® Canine is 2 mg/lb body weight (.02 mL/lb, or 1 mL per 50 lb), by intramuscular injection only, twice weekly for up to 4 weeks (maximum of 8 injections). Do not exceed the recommended dose or therapeutic regimen.
Do not mix Adequan ® Canine with other drugs or solvents.
Storage Conditions: Store at controlled room temperature up to 25°C (77°F) (See USP).

How Supplied: Adequan ® Canine Solution 100 mg/mL in a 5 mL preserved multiple dose vial. Product ID # 97502 5 mL Multiple Dose Vials Packaged 2 vials per box

[gruvi]

Go Yafu.:cool:

[kingchaney]

In response to giff ... I'm looking for adequan to help with my aching left shoulder and left knee. I've been hitting the iron for over a dozen years and went from 151 to 221 lbs during that time. I have a lot of wear and tear in my joints. I've had several x-rays and MRI's the past three years to try to get to the bottom of things. I'm told I have degenerative changes in my joints which is basically the beginning of osteoarthritis. I'm in pain and my workouts are suffering especially bench and squat. I've done my research on adequan and read lots of posts on this forum but I'm unable to locate a merchant that doesn't require a prescription.

[giff]

In response to giff ... I'm looking for adequan to help with my aching left shoulder and left knee. I've been hitting the iron for over a dozen years and went from 151 to 221 lbs during that time. I have a lot of wear and tear in my joints. I've had several x-rays and MRI's the past three years to try to get to the bottom of things. I'm told I have degenerative changes in my joints which is basically the beginning of osteoarthritis. I'm in pain and my workouts are suffering especially bench and squat. I've done my research on adequan and read lots of posts on this forum but I'm unable to locate a merchant that doesn't require a prescription.

then take a break supplement with glycosamine and use some deca helps joins (lubricates them) stay away from horse shit

[kingchaney]

then take a break supplement with glycosamine and use some deca helps joins (lubricates them) stay away from horse shit

I hear you bro and I appreciate your advice, but it's advice I've completed several times over. 5 out of my 8 cycles included deca (my nipples hurt just thinking about it) but it destroyed my cardio (I NEED to keep my running on great terms because I'm active duty army) and I've taken/currently taking everything from glucosamine, fish oils, MSM, white willow bark extract, chondroitin sulfate, shark cartilage, and the list gets longer every couple of months. I've spent more on this shit than gear over the last three years. Plus I've taken more breaks from the iron than a fat man on a treadmill. It's hard trying to keep what I've worked for by not being in the gym. I know Alin sells aflutop but I'm hearing better responses from adequan.

[yafu]

No source fishing!
Take some Ranger candy and suck it up or see the doctor and get a medical.

[kingchaney]

No source fishing!
Take some Ranger candy and suck it up or see the doctor and get a medical.

Sorry Yafu. I don't mean to direspect this forum or any of it's members by source fishing. Trust me bro, I'm taking my candy and dealing with the pain but that's not going to regenerate my joints. And for medical, I'm over the hump and 8 out from retirement, ... that's not an option.

Plus I've searched the adequan topic and read many posts on it, and members claim they will pm info/source if interested but I'm not receiving replys to my pm's. I did recieve one from a member saying I'm too new on this forum and to put in work then people will respond. My response to that is, I've been a member for over a year and a half but haven't posted much because I've been in Iraq the majority of that time and didn't have net access. When I did get the opportunity to get on this forum during that time, I conducted searches, gathered info, increased my knowledge, and went about my way ... I didn't have time to post, post, post.

Yafu, I'm thick skinned and I've seen several malicious replys out there toward would-be noobs. If some are coming my way, then so be it. I'm trying to play catch up so whatever advice is rendered in the post is greatly appreciated.

[giff]

Sorry Yafu. I don't mean to direspect this forum or any of it's members by source fishing. Trust me bro, I'm taking my candy and dealing with the pain but that's not going to regenerate my joints. And for medical, I'm over the hump and 8 out from retirement, ... that's not an option.

Plus I've searched the adequan topic and read many posts on it, and members claim they will pm info/source if interested but I'm not receiving replys to my pm's. I did recieve one from a member saying I'm too new on this forum and to put in work then people will respond. My response to that is, I've been a member for over a year and a half but haven't posted much because I've been in Iraq the majority of that time and didn't have net access. When I did get the opportunity to get on this forum during that time, I conducted searches, gathered info, increased my knowledge, and went about my way ... I didn't have time to post, post, post.

Yafu, I'm thick skinned and I've seen several malicious replys out there toward would-be noobs. If some are coming my way, then so be it. I'm trying to play catch up so whatever advice is rendered in the post is greatly appreciated.

to be honest bro i dont think alot of people would have to much info on it for you. its a difficult one and as for myself i certainly dont have any more info on it that you would appreciate. keep looking and stick around its a good board. one piece of advice though keep looking for other options. i know it sounds lame but there are alot of alternatives people dont think about like herbal maybe massage etc. just an option

[kingchaney]

to be honest bro i dont think alot of people would have to much info on it for you. its a difficult one and as for myself i certainly dont have any more info on it that you would appreciate. keep looking and stick around its a good board. one piece of advice though keep looking for other options. i know it sounds lame but there are alot of alternatives people dont think about like herbal maybe massage etc. just an option

Thanks giff. Although, I do appreciate your advice. I'm open minded and I know there a several ways to get to the finish line. I'll be around and whatever people can input is cool. Thanks again.