PDA

View Full Version : Test Levels Active Life In The Bloodstream


GetStrongNow
05-31-2008, 07:12 PM
The long post below about esters caused me to remember some (just a little) Chemistry from 20+ years ago in college.

If you have an active molecule (testosterone) attached to a carrying ester (say propionate), for it to become active, it has to disassociate from the carrying ester. This happens at some rate, don't remember if the disassociation is governed by 1/2 life statistics. Then as I have read other places, really only the "free" testosterone is active -- the reaction from bound to free may be governed by some conversion statistics. Then, the free test will have some lifetime decay as well, that probably IS governed by 1/2 life statistics.

So, the amount of test actually active in the system over time is a combination of the 3 reactions: disassociation from the ester, conversion from bound to free, and decay.

Despite a lot of searching, I have never seen any other "activity" times, other than the standard 3-4 days for prop, 10-12 for enan, 12-14 for cyp, kind of stuff. Would seem to me that these are the disassociation times, not the full activity times, and that would make some difference in how people should plan and time their PCT.

Comments (including if I am just full of shit)?

BTW, I have been juicing for 4+ years with 10+ cycles, and at my age 46 cruise in between with a little cyp and deca. Having said the above, my experience is similar to McCollums, its more important how well you work out vs. having an over complicated stack worrying about timings and differences,
and more is not necessarily better.

Machola
05-31-2008, 08:19 PM
So, the amount of test actually active in the system over time is a combination of the 3 reactions: disassociation from the ester, conversion from bound to free, and decay.

majority of test will go from bound to ester to bound to protein. only 2% of testosterone is free to hook up to androgen receptors. most of it is bound to albumin and shbg. shbg is a big factor. thats why proviron makes free test levels skyrocket.

my experience is similar to McCollums, its more important how well you work out vs. having an over complicated stack worrying about timings and differences,
and more is not necessarily better.
eating and training is most important. supplementation is secondary.